Piperine (or Piperaceae) is the active compound in black pepper. When taken as a dietary supplement, Piperine has the ability to significantly improve the absorption and uptake of many dietary supplements. Piperine is used for its ability to inhibit phase 2 detoxifying enzymes and to prevent the process of glucuronidation. Piperine may also slow intestinal removal of supplements. These effects allow your body to better absorb many supplements (non-endogenous supplements that are metabolized by the liver).
Key Mechanisms of Piperine:
This active compound has significant and profound effects on metabolic enzymes in the liver and intestine.
It may induce alterations in membrane dynamics and permeation characteristics, along with an increase in absorptive surface area in the small intestine.
This supplement affects the P-glycoprotein-mediated efflux system, via modulation of functional activities and gene expression of P-Glycoprotein.
Some research has pointed to a dose-dependent increase in gastric acid secretion and a delay in gastrointestinal motility.
This supplement may have a profound and serving-size-dependent effect on the uptake and absorption of many supplements. However, it needs to be used responsibly, and special care should be taken to avoid using this supplement in combination with pharmaceutical agents, unless under the strict supervision of a qualified doctor (because of its potential to increase effects or affect uptake/metabolism).
The recommended serving size for Piperine is 20mg. Do not use Piperine if you are taking any medication.